Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN326)
DME Name Aminoglycoside 3'-phosphotransferase (aphA), Escherichia coli
Gene Name aphA
UniProt ID
KKA8_ECOLX
EC Number    EC: 2.7.1.95     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.95
Lineage    Species: Escherichia coli     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Escherichia coli
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MNDIDREEPCAAAAVPESMAAHVMGYKWARDKVGQSGCAVYRLHSKSGGSDLFLKHGKDA
FADDVTDEMVRLRWLAGHISVPSVVSFVRTPNQAWLLTTAIHGKTAYQVLKSDFGARLVV
VDALAAFMRRLHAIPVSECSVQQWTTHAGLPERGSIEAGVVDVDDFDKEREGWTAEQVWE
AMHRLLPLAPDPVVTHGDFSLDNLLIVEGKVVGCIDVGRAGIADRYQDLAVLWNCLEEFE
PSLQERLVAQYGIADPDRRKLQFHLLLDELF
Function Resistance to kanamycin and structurally-related aminoglycosides, including amikacin.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Sisomicin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR006816 Sisomicin Unclear Unclear - Unclear Sisomicin [1]
References
1 Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen. Antimicrob Agents Chemother. 2013 Jan;57(1):452-7.

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