General Information of DME (ID: DMEN385)
DME Name	Catechol 1,2-dioxygenase (catA), .
Gene Name	catA
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME

Full List of Drug(s) Metabolized by This DME
Drugs Approved by FDA			Click to Show/Hide the Full List of Drugs:          3 Drugs
Remdesivir	Drug Info	Approved	Coronavirus Disease 2019 (COVID-19)	ICD11: 1D6Y	[1], [2]
Naproxen	Drug Info	Approved	Rheumatoid arthritis	ICD11: FA20	[3]
Sofosbuvir	Drug Info	Approved	Viral hepatitis	ICD11: 1E51	[4]
Drugs in Phase 2 Clinical Trial			Click to Show/Hide the Full List of Drugs:          1 Drugs
INX-189	Drug Info	Phase 2	Hepatitis C virus infection	ICD11: 1E50-1E51	[5]
Drugs in Phase 1 Clinical Trial			Click to Show/Hide the Full List of Drugs:          1 Drugs
GS-6620	Drug Info	Phase 1	Hepatitis C virus infection	ICD11: 1E50-1E51	[6]

Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF MR004868 Catechol Cis-cis muconic acid Unclear - Unclear Naproxen [3]

References
1	Human carboxylesterase 1A plays a predominant role in the hydrolytic activation of remdesivir in humans
2	Viral target and metabolism-based rationale for combined use of recently authorized small molecule COVID-19 medicines: Molnupiravir, nirmatrelvir, and remdesivir
3	Utilization of naproxen by Amycolatopsis sp. Poz 14 and detection of the enzymes involved in the degradation metabolic pathway
4	Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.
5	In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2'-C-Methylguanosine Prodrug BMS-986094 : Potential Role in Clinical Cardiovascular Toxicity
6	Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.