Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN809)
DME Name peptidases (PPD), Homo sapiens
Gene Name PPD
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Carfilzomib
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR010450 Oprozomib PR-025 Unclear - Unclear Oprozomib [2]
MR010453 Oprozomib Oprozomib Metabolite M5 Unclear - Unclear Oprozomib [2]
MR010449 PR-176 Oprozomib Metabolite M3 Other reaction - Cleavage Oprozomib [2]
References
1 Proteasome Inhibitors and Their Pharmacokinetics, Pharmacodynamics, and Metabolism Int J Mol Sci. 2021 Oct 27;22(21):11595. doi: 10.3390/ijms222111595.
2 In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s

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