Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN826)
DME Name Cytochrome P450 2D (CYP2D), Bacteroides fragilis
Gene Name CYP2D
Lineage    Species: Bacteroides fragilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides fragilis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
MEDETOMIDINE
 Drug Info Phase 2 Pain ICD11: MG30-MG3Z [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012639 Medetomidine Dehydromedetomidine Unclear - Unclear Medetomidine [1]
MR012218 PD-153035 PD-153035 M1 Oxidation - N-oxidation PD-153035 [2]
MR012219 PD-153035 PD-153035 M2 Oxidation - 7-O-desmethylation PD-153035 [2]
MR012220 PD-153035 PD-153035 M3 Oxidation - O-demethylation PD-153035 [2]
References
1 Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes. Biomed Chromatogr. 2010 Aug;24(8):868-77.
2 Metabolism of epidermal growth factor receptor targeting probe [11C]PD153035: impact on biodistribution and tumor uptake in rats

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