Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME0585)
DME Name Pyridoxal phosphate phosphatase (PDXP), Homo sapiens
Synonyms Chronophin; PLP phosphatase; Pyridoxalphosphate phosphatase; PDXP; CIN; PLP; PLPP
Gene Name PDXP
UniProt ID
PLPP_HUMAN
Gene ID
57026
EC Number    EC: 3.1.3.74     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.74
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MARCERLRGAALRDVLGRAQGVLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNN
SRRARPELALRFARLGFGGLRAEQLFSSALCAARLLRQRLPGPPDAPGAVFVLGGEGLRA
ELRAAGLRLAGDPSAGDGAAPRVRAVLVGYDEHFSFAKLREACAHLRDPECLLVATDRDP
WHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFECITENFSIDPARTLMVGDRL
ETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAGQHDLVPHYYVESIADLTEGLED
Structure
2CFR ; 2CFS ; 2CFT ; 2OYC ; 2P27 ; 2P69 ; 5GYN
Pathway Metabolic pathways (hsa01100 )
Vitamin B6 metabolism (hsa00750 )
Function This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. It participates in vitamin B6 metabolism.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Vitamin B6
 Drug Info Phase 4 Functional nausea/vomiting ICD11: DD90 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR006228 Vitamin B6 Pyridoxal 5'-phosphate Conjugation - Phosphorylation Vitamin B6 [1]
References
1 Purification and characterization of vitamin B6-phosphate phosphatase from human erythrocytes. J Biol Chem. 1992 Aug 5;267(22):15978-83.

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