Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1016)
DME Name Beta-lactamase (blaB), Prevotella melaninogenica
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; cfxa2
Gene Name cfxa2
UniProt ID
Q8KT52_9BACT
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Prevotella melaninogenica     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella melaninogenica
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MEKNRKKQIVVLSIALVCIFILVFSLFHKSATKDSANPPLTNVLTDSISQIVSACPGEIG
VAVIVNNRDTVKVNNKSVYPMMSVFKVHQALALCNDFDNKGISLDTLVNINRDKLDPKTW
SPMLKDYSGPVISLTVRDLLRYTLTQSDNNASNLMFKDMVNVAQTDSFIATLIPRSSFQI
AYTEEEMSADHNKAYSNYTSPLGAAMLMNRLFTEGLIDDEKQSFIKNTFKECKTGVDRIA
APLLDKEGVVIAHKTGSGDVNENGVLAAHNDVAYICLPNNISYTLAVFVKDFKGNESQAS
QYVAHISAVVYSLLMQTSVKS
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1], [2]
Penicillin G
 Drug Info Approved Diphtheria ICD11: 1C17 [2]
References
1 Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24.
2 Antimicrobial drugs used in the management of anaerobic infections in children. Drugs. 1983 Dec;26(6):520-9.

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