Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1017)
DME Name Beta-lactamase (blaB), Odoribacter splanchnicus
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; Odosp_1620
Gene Name blaB
UniProt ID
F9Z530_ODOSD
Gene ID
41366452
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Odoribacter splanchnicus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Odoribacteraceae
Genus: Odoribacter
Species: Odoribacter splanchnicus
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKSRKWKKISALLFLGIALLFLLMPTYMQEALIHWFPDISDTYIFPSDTVGKADSCWEWP
VARDANRYRMTDDEEAYLEKYGTVAYLVIQDDSIRYEEYREDWTPQKLSNIFSATKSIVG
LLVGIAYDEGFIESLDDKVSKYLPEFGEGDKITIRNLLTMSSGLDWDEAYTALISKTTQA
YYGDRIRDLIMDLKVVEEPGKKYSYKSGDTQLLSFVLEAALDKVHKEKEYEWGIFKTEVK
VHSPVSISEYAERKLWKPLGACNDALWNLDREDGDEKTYCCFNTTARDLARLGRLILNKG
NWNGRQLISETYLNEAITPAGYLENEFGDGSLDYYGFQIWIMHYKEMRFPAFRGLGGQYM
FVIPQKNAIVIRLGHKRSDEYIREKTIDMDAYLDIAFKILE
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1], [2]
Ticarcillin
 Drug Info Approved Infectious cystitis ICD11: GC00 [2]
References
1 Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50.
2 Effect of CO2 on susceptibilities of anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin. Antimicrob Agents Chemother. 1994 Feb;38(2):211-6.

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