Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1211)
DME Name Beta-glucuronidase (uidA), Lactobacillus rhamnosus
Synonyms Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; BGK71_00200; CCE29_06935; FEZ43_12625; NCTC13710_00049; PY91_01090; uidA
Gene Name uidA
UniProt ID
A0A2A5L2J1_LACRH
Gene ID
8420464
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Lactobacillus rhamnosus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus rhamnosus
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
METSLLYPVTNDQRTDQKLDGLWQFKFDEAGEGEKSGWETGFHDGVSMPVPASFNDFFTD
KASREYTGDFWYSRNFFVPSAAKGKALFLRFDAVTHRATIFVNGKEIRTHEGGFLPFAAD
ISEAVKYGAENTVVVKGNNELSREALPAGDTITLRNGKKMVRPFFDFYNYSGLNRSVHLL
SLPQERVLDYTTTFALAGNDATVNYTVETNGDAPVTVSLADADGQVVATAQGKQGALQVQ
NAHLWQVRNAYLYTLTIQLGDDTQTPLDTYTDRIGIRTIKISGTDILVNDKPIYLKGFGR
HEDSPFAGRAFDLNVEKKDFALMKWIGANSFRTSHYPYDEQVYKIADEEGFLLTDEVPAV
GFKMAAAAFLGGLNQSFFKGPWLKKLHERHIDQIRDLIKRDKNHPSVLAWSLFNEPDTID
ENAVPYFKQIFDESKDLDPQGRPRTFTLSEDDTIETSKVLDFPDFYMLNRYPGWYHFGGY
QISDGEAGLRDEMDKWQKAGVKKPVVFTEFGADTEAGLHKLPSVMWTEEYQVEVLKMFSR
VFDDYDFIKGEQVWNLADFQTVEGNMRVNGNKKGIFTRDRQPKAAAFFYHDRWNKLPLDY
KAK
Structure
6ECA
Function This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Diclofenac glucuronide
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.

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