Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1257)
DME Name Unclear metabolic mechanism (DME-unclear), Bifidobacterium longum
Gene Name DME-unclear
Lineage    Species: Bifidobacterium longum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium longum
Subspecies: Bifidobacterium longum R0175
Subspecies: Bifidobacterium longum subsp. infantis CCUG 52486
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        13 Drugs
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Fluoxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Famciclovir
 Drug Info Approved Genital herpes ICD11: 1A94 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Lovastatin
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [2]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Olmesartan medoxomil
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          3 Drugs
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Racecadotril
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
Roxatidine
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
BE-14348A
 Drug Info Phase 1 Viral hepatitis ICD11: 1E51 [3]
BRN-0498823
 Drug Info Phase 1 Essential hypertension ICD11: BA00 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          5 Drugs
AS-63093
 Drug Info Preclinical Allergy ICD11: 4A80 [3]
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Dihydro-coumaric acid
 Drug Info Investigative Discovery agent ICD: N.A. [3]
FT-0669759
 Drug Info Investigative Discovery agent ICD: N.A. [3]
Phloretic acid
 Drug Info Investigative Discovery agent ICD: N.A. [3]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 In vitro susceptibility of cultured human methanogens to lovastatin. Int J Antimicrob Agents. 2017 Feb;49(2):176-182.
3 Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.

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