General Information of DME (ID: DME1307)
DME Name Glutamate decarboxylase (gadB), Bifidobacterium dentium
Synonyms Glutamic acid decarboxylase; Bacterial glutamate--ammonia ligase; gad; gadB; BDP_1749; GAD-beta
Gene Name gadB
UniProt ID
D2Q5X3_BIFDB
Gene ID
31606910
EC Number    EC: 4.1.1.15     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.15
Lineage    Species: Bifidobacterium dentium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium dentium
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSIMHSNINTIAAGYGYSGGADSDSVEVNPLFARPKEAKAFSKFKIPQEGSLPETAYQVV
HDDAMLDGNARLNLATFVSTWMDDYANRLYMEAADKNMIDKDEYPKTAEVESRCWHMLAD
LWHAPDPMNTIGTSTIGSSEACMLGGLALKRRWKEAREKAGLPADRPNLVMSSAVQVCWE
KFCNYFDVEPRYVPISEEHKVLDGYDLDKYVDENTIGVVAIMGVTYTGMYEPVKKISDAL
DRIEERTGLDVRIHVDAASGGMIAPFIQPDLQWDFRVKRVYSISTSGHKYGLVYPGLGWV
VWRETADLPESLIFKVSYLGGEMPTFALNFSRPGAQVLLQYYMFLRLGFEGYRRVQQAAH
DVAKYLSGEIAKMDDFTLWNDGSDIPVFAWMLKDKPDRKWNLYDLQDRLRMKGWLVPAYP
MPVDLTQVTVQRIVVRNGFSHDMAESFLKDLKACVKYLDGLKAPMPSEARVSGFHH
Pathway Alanine, aspartate and glutamate metabolism (bde00250 )
Biosynthesis of secondary metabolites (bde01110 )
Butanoate metabolism (bde00650 )
Metabolic pathways (bde01100 )
Microbial metabolism in diverse environments (bde01120 )
Quorum sensing (bde02024 )
Taurine and hypotaurine metabolism (bde00430 )
beta-Alanine metabolism (bde00410 )
Function This enzyme acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
L-glutamine
Drug Info Approved Sickle-cell anaemia ICD11: 3A51 [1]
References
1 GABA production and structure of gadB/gadC genes in Lactobacillus and Bifidobacterium strains from human microbiota. Anaerobe. 2016 Dec;42:197-204.

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