Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1480)
DME Name Alpha-L-rhamnosidase (lrA), Bacillus subtilis
Synonyms Alpha-L-rhamnosidase T; Alpha-L-rhamnosidase N; Alpha-L-rhamnoside rhamnohydrolase; DOE78_02545
Gene Name DOE78_02545
UniProt ID
A0A385NJR4_9BACI
EC Number    EC: 3.2.1.40     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.40
Lineage    Species: Bacillus subtilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus subtilis
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSFKRSLIIVLSFLLTFSLLYPVTETVEASPPGTITNLQVEYMENPIGVDSENPRFSWNM
VSNVRGAKQLAYELVIADSEKNLKQGEYVWSSRKVTSSQSVNVKYTGEAKLTASTRYFWK
VKVWDQDNKVLESKQNAFFETGLMSKDGTTNWDGAQWITNNKAATDPVNVTLFRTEQKVT
NKPIQNAQLYISSLGIYEAFINGKEVQLLQGQEQAVDETFNPGWTDYNSYVNYQAYDVTS
YLSNKSHLSLGVMVGKGWYAGRIGQVGQYTKVSGNKLALLAKLVITYKDGSTDVIVTNES
NWKSSEKSPIKSNDFFDGETYDAIVAKEIEGWNNVKYDDSEWSPVSSFIYKGEVKGSRAA
AARVAEEYTQQPIGAYKYSEIEQSVQNGGESSYDFGHAITTKVKPNSTIHLKAGEILIVD
MGQNMAGVPNIKVSGDTGSTVTMRFAEMINDGKKNPKIMSGGSDGPKDTLYRKALTSAAQ
TDKYILSGQGVEEYQPVFTFHGYRYMEVTADADLRIHSAEGKVITSVKDQTGDITTSNSD
VNKLFSNVLWGQRSNYLSIPTDSPQRAERAGWTGDAQLFAQSAVYNYNDFSFLENYSEIM
DTHNKNNNGIYGSIMPGAFVGFFANTVASGWSDSGIIIPWVLYQQTGDTTVIEKNFAQME
KYMDYVEKSGYNTGLFGDWLAFQATSTVYLNTIYRAYDAQLMAKMAKVIGNETAVDKYEE
LYAKTKSDFVNKYFDDKGNLLTASADNFTQSRHGYPGADNAQTGLLWALKLGLYETEQQR
ETMVQNLTANIKNEGSLIRPGQPENTLAVGFLGVNVLLPTLSDIGDNDLAYTLLLQDEMP
SWLYSVKNGATTIWERWNSYSIEDSFGDSGMNSFNHYSYGAVAEWMYKYMAGISNDPEKP
GFQHFVLQPTIDGENRISWVNGSYDSVYGEIKSNWKVENGTFKYQVTIPANTSATLAIPA
TNVNEVTEGGVSLSKAKGIKVIEVKDGKVYCEVSSGTYDITSKVN
Function This enzyme utilizes an inverting mechanism of hydrolysis, releasing beta-L-rhamnose. Substrates include naringin, rutin, quercitrin, hesperidin, dioscin, terpenyl glycosides and many other natural glycosides containing terminal alpha-L-rhamnose.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BRN-0075455
 Drug Info Phase 2/3 Diabetes mellitus ICD11: 5A10 [1]
References
1 Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100.

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