Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1691)
DME Name Pyruvate oxidase (pyrO), Lactobacillus casei
Synonyms Pyruvate dehydrogenase; Pyruvic oxidase; POX; AAW28_13255; AUQ39_11915
Gene Name pyrO
UniProt ID
A0A0H0YI92_LACCA
EC Number    EC: 1.2.3.3     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Aldehyde/oxo donor oxidoreductase
Oxygen acceptor oxidoreductase
EC: 1.2.3.3
Lineage    Species: Lactobacillus casei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus casei
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MATKAADQLVSVLMDWQVKHVFGLPGDSIDTTVDALRRHQDKIKFVQVRHEEVAALAASA
TAKLTGGLGVCLSIGGPGAIHLLNGLYDAKMDHAPVLALLGQVTTSNLNEGFFQEVNTPK
LFDDVAVYNKTVMASDNLGQIVDTAIRTAFTEKGVAVLTIPDDLPDQKETTSYRDSAAAF
ALNVPEVDPKQLDDVASLLQKSQKPLALIGRGAEHAGEQVQKFVEANHIPFIQTMPAKGT
VADDHPNSLGNVGKLGTKPAYEAMKATDLLFMIGTNYPYTPYLPDEGQAKCVQIDTQPEN
LGKRYSVDVAVDGDVETFLTELNAKGSLRDDDRFLKACQKNMESWDKWMAEKRLLTTNPA
SPEAVFATIDQTAPKDAVYSVDVGTSTSWGARFLNVQPTQKYTISAWLGTMGCGLPGAIA
GAEAFPKRQNISVAGDGAFAMVMQDFVTAVKYKLPIIMVVLNNQKLAFIEYEQQSAGQLN
YEIDLADMDYAKIAEAAGGVGYTAHSNDEFKEALTKAYQETEKPVLINTYVQDDAPLPGK
IVGEEAKGYMKYGSQYLENYWKIPSMPPLKDIMRQFF
Function This enzyme is a flavoprotein (FAD) requiring thiamine diphosphate. Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavin.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
DB-053072
 Drug Info Phase 1 Prostate cancer ICD11: 2C82 [1]
References
1 Metabolic gene-targeted monitoring of non-starter lactic acid bacteria during cheese ripening. Int J Food Microbiol. 2017 Sep 18;257:276-284.

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