Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1880)
DME Name Beta-lactamase (blaB), Klebsiella aerogenes
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; Beta-lactamase SHV-1; PIT-2; bla; shv1
Gene Name bla
UniProt ID
BLA1_KLEPN
Gene ID
39633152
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Klebsiella aerogenes     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella aerogenes
Subspecies: Klebsiella aerogenes KUN4843
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADE
RFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCA
AAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPA
SMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARG
IVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
Structure
1ONG ; 1Q2P ; 1RCJ ; 1SHV ; 1TDG ; 1TDL ; 1VM1 ; 2A3U ; 2A49 ; 2G2U ; 2G2W ; 2H0T ; 2H0Y ; 2H10 ; 2H5S ; 3D4F ; 3MKE ; 3MKF ; 3MXR ; 3MXS ; 3N4I ; 3OPH ; 3OPL ; 3OPP ; 3OPR ; 3V50 ; 3V5M ; 4FCF ; 4FD8 ; 4FH2 ; 4FH4 ; 4GD6 ; 4GD8 ; 4GDB ; 4JPM ; 4MBF ; 4MBH ; 4MBK ; 4R3B ; 4ZAM ; 5EE8
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
References
1 Interspecies dissemination of a mobilizable plasmid harboring blaIMP-19 and the possibility of horizontal gene transfer in a single patient. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5412-9.

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