Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN034)
DME Name Demethylmenaquinone methyltransferase (menG), Staphylococcus aureus
Gene Name menG
UniProt ID
MENG_STAAM
EC Number    EC: 2.8.2.1     (Click to Show/Hide the Complete EC Tree)
Transferase
Sulfotransferase
Sulfotransferase
EC: 2.8.2.1
Lineage    Species: Staphylococcus aureus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacillota
Class: Bacilli
Order: Bacillales
Family: Staphylococcaceae
Genus: Staphylococcus
Species: Staphylococcus aureus
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MADNKANKEQVHRVFQNISKKYDRLNNIISFEQHKVWRKRVMKDMGVRKGTKALDVCCGT
GDWTIALSKAVGPTGEVTGIDFSENMLEVGKEKTASMENVKLVHGDAMELPFEDNSFDYV
TIGFGLRNVPDYLVALKEMNRVLKPGGMVVCLETSQPTLPVFKQMYALYFKFVMPIFGKL
FAKSKEEYEWLQQSTFNFPGKEELKRMFEEAGFINVRVRSFTGGVAAMHLGYKEKDNTKG
D
Function Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
ACMC-209hn7
 Drug Info Investigative Ulcerative colitis ICD11: DD71 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR000055 DMK Menaquinone Unclear - Unclear ACMC-209hn7 [1]
References
1 Identification of six important amino acid residues of MenA from Bacillus subtilis natto for enzyme activity and formation of menaquinone Enzyme Microb Technol. 2020 Aug;138:109583. doi: 10.1016/j.enzmictec.2020.109583.

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