Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN087)
DME Name N-acetylgalactosamine-7-sulfatase (GALNS), Homo sapiens
Gene Name GALNS
UniProt ID
GALNS_HUMAN
EC Number    EC: 3.1.6.4     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Sulfuric ester hydrolase
EC: 3.1.6.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLD
RMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDS
EQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPV
YRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVY
ASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQG
GSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSD
RAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCP
GQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALV
PAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH
Structure
4FDI ; 4FDJ
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Chondroitin sulfate
 Drug Info Phase 4 Osteoarthritis ICD11: FA00 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR003570 Chondroitin sulfate Cs_a_deg4 Hydrolysis - Hydrolysis Chondroitin sulfate [1]
MR003599 Chondroitin sulfate Cs_a_deg1 Hydrolysis - Hydrolysis Chondroitin sulfate [1]
MR003600 Chondroitin sulfate Cs_e_deg1 Hydrolysis - Hydrolysis Chondroitin sulfate [1]
MR003601 Chondroitin sulfate Cs_e_deg5 Hydrolysis - Hydrolysis Chondroitin sulfate [1]
MR003602 Chondroitin sulfate Sulfate Hydrolysis - Hydrolysis Chondroitin sulfate [1]
MR003583 Cs_d_deg2 Cs_c_deg5 Hydrolysis - Hydrolysis Chondroitin sulfate [1]
MR003584 Cs_d_deg2 Cs_d_deg3 Hydrolysis - Hydrolysis Chondroitin sulfate [1]
MR003585 Cs_d_deg2 Sulfate Hydrolysis - Hydrolysis Chondroitin sulfate [1]
⏷ Show the Full List of 8 MR(s)
References
1 DrugBank(Pharmacology-Metabolism):Chondroitin?sulfate

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