| General Information of DME (ID: DMEN106) |
| DME Name |
isocitrate dehydrogenase (IDH1), Homo sapiens
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| Gene Name |
IDH1
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| UniProt ID |
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| EC Number |
EC: 1.1.1.42 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.42
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
|
| Sequence |
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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| Structure |
1T09
; 1T0L
; 3INM
; 3MAP
; 3MAR
; 3MAS
; 4I3K
; 4I3L
; 4KZO
; 4L03
; 4L04
; 4L06
; 4UMX
; 4UMY
; 4XRX
; 4XS3
; 5DE1
; 5GIR
; 5K10
; 5K11
; 5L57
; 5L58
; 5LGE
; 5SUN
; 5SVF
; 5TQH
; 5YFM
; 5YFN
; 6ADG
; 6B0Z
; 6BKX
; 6BKY
; 6BKZ
; 6BL0
; 6BL1
; 6BL2
; 6IO0
; 6O2Y
; 6O2Z
; 6PAY
; 6Q6F
; 6U4J
; 6VEI
; 6VG0
; 7PJM
; 7PJN
; 8BAY
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| Function |
Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase . Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways . May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity).
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