Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN226)
DME Name Aminoglycoside N(3)-acetyltransferase III (aacC3), Pseudomonas aeruginosa
Gene Name aacC3
UniProt ID
AACC3_PSEAI
EC Number    EC: 2.3.1.81     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.81
Lineage    Species: Pseudomonas aeruginosa     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Pseudomonas aeruginosa
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MTDLNIPHTHAHLVDAFQALGIRAGQALMLHASVKAVGAVMGGPNVILQALMDALTPDGT
LMMYAGWQDIPDFIDSLPDALKAVYLEQHPPFDPATARAVRENSVLAEFLRTWPCVHRSA
NPEASMVAVGRQAALLTANHALDYGYGVESPLAKLVAIEGYVLMLGAPLDTITLLHHAEY
LAKMRHKNVVRYPCPILRDGRKVWVTVEDYDTGDPHDDYSFEQIARDYVAQGGGTRGKVG
DADAYLFAAQDLTRFAVQWLESRFGDSASYG
Structure
7MQK ; 7MQL ; 7MQM ; 7Q0Q ; 7Q10 ; 7Q1D ; 7Q1X
Function Resistance to antibiotics containing the 2-deoxy-streptamine ring including dibekacin, gentamicin, kanamycin, sisomicin, tobramycin and neomycin, but not to amikacin or netilmicin . Acetylates a broad range of both 4,5- and 4,6-disubstituted aminoglycosides, including neomycin, paromomycin, ribostamycin, sisomicin, gentamicin, tobramycin and kanamycin, with no preference of one disubstitution over the other. Acetylates sisomicin and kanamycin most and least efficiently, respectively. Does not modify plazomicin .
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Dibekacin
 Drug Info Phase 4 Acute lower respiratory infection ICD11: CA4Z [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004598 Dibekacin 3-N-Acetyldibekacin Unclear - Unclear Dibekacin [1]
References
1 The novel enzymatic 3''-N-acetylation of arbekacin by an aminoglycoside 3-N-acetyltransferase of Streptomyces origin and the resulting activity. J Antibiot (Tokyo). 1998 Aug;51(8):735-42.

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