Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN273)
DME Name Fructose-bisphosphate aldolase B (ALDOB), Homo sapiens
Gene Name ALDOB
UniProt ID
ALDOB_HUMAN
EC Number    EC: 4.1.2.13     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Peptidyl-dipeptidases
EC: 4.1.2.13
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MAHRFPALTQEQKKELSEIAQSIVANGKGILAADESVGTMGNRLQRIKVENTEENRRQFR
EILFSVDSSINQSIGGVILFHETLYQKDSQGKLFRNILKEKGIVVGIKLDQGGAPLAGTN
KETTIQGLDGLSERCAQYKKDGVDFGKWRAVLRIADQCPSSLAIQENANALARYASICQQ
NGLVPIVEPEVIPDGDHDLEHCQYVTEKVLAAVYKALNDHHVYLEGTLLKPNMVTAGHAC
TKKYTPEQVAMATVTALHRTVPAAVPGICFLSGGMSEEDATLNLNAINLCPLPKPWKLSF
SYGRALQASALAAWGGKAANKEATQEAFMKRAMANCQAAKGQYVHTGSSGAASTQSLFTA
CYTY
Structure
1QO5 ; 1XDL ; 1XDM ; 8D44
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
LS-69767
 Drug Info Phase 1 Chronic myelogenous leukaemia ICD11: 2A20 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR005787 Fructose-1-phosphate Dihydroxyacetone phosphate Unclear - Unclear LS-69767 [1]
MR005789 Fructose-1-phosphate Glyceraldehyde Unclear - Unclear LS-69767 [1]
References
1 Toxin and Toxin Target Database (T3DB):LS-69767

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