Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN813)
DME Name 3 alpha-hydroxysteroid dehydrogenase (HSD3A), Homo sapiens
Gene Name HSD3A
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR010813 5alpha-NET 3alpha,5alpha-NET Unclear - Unclear Norethindrone [1]
MR010814 5alpha-NET 3beta,5alpha-NET Unclear - Unclear Norethindrone [1]
MR011794 3-keto-5alpha-Gal 3alpha-OH-5alpha-Gal Unclear - Unclear TOK-001 [2]
MR011793 3-keto-5beta-Gal 3alpha-OH-5beta-Gal Unclear - Unclear TOK-001 [2]
References
1 Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22.
2 Steroidogenic Metabolism of Galeterone Reveals a Diversity of Biochemical Activities

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