Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN822)
DME Name Cathepsin B (CTSB), Homo sapiens
Gene Name CTSB
UniProt ID
CATB_HUMAN
EC Number    EC: 3.4.22.1     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Cysteine protease
EC: 3.4.22.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Structure
1CSB ; 1GMY ; 1HUC ; 1PBH ; 2IPP ; 2PBH ; 3AI8 ; 3CBJ ; 3CBK ; 3K9M ; 3PBH ; 5MBL ; 5MBM ; 6AY2
Function Thiol protease which is believed to participate in intracellular degradation and turnover of proteins . Cleaves matrix extracellular phosphoglycoprotein MEPE . Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis .
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
T-0128
 Drug Info Phase 1 Solid tumour/cancer ICD11: 2A00-2F9Z [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR013625 T-0128 T-2513 Unclear - Unclear T-0128 [1]
References
1 Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors

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