| General Information of Drug Metabolite (DM) (ID: DM000205) |
| DM Name |
Lamotrigine-5-N-glucuronide
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 1A3 (UGT1A3)
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DME0041
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| Conjugation - Glucuronidation |
Lamotrigine
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[1] , [2] , [3] |
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UDP-glucuronosyltransferase 1A4 (UGT1A4)
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DME0048
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| Conjugation - Glucuronidation |
Lamotrigine
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[1] , [2] , [3] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Lamotrigine |
DR0913
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Approved |
Bipolar disorder |
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| References |
| 1 |
Pharmacokinetics, toxicology and safety of lamotrigine in epilepsy Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):1009-18. doi: 10.1517/17425255.2.6.1009.
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| 2 |
Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 2009 Nov;39(11):826-35.
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| 3 |
UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers. Xenobiotica. 2021 Oct;51(10):1146-1154. doi: 10.1080/00498254.2021.1972492.
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