Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000420)
DM Name	Glutathione conjugation of tacrine

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Glutathione S-transferase mu-1 (GSTM1)	DME0308	Tacrine hydrochloride	Conjugation - Glutathione Conjugation	Tacrine hydrochloride	[1]
Glutathione S-transferase theta-1 (GSTT1)	DME0093	Tacrine hydrochloride	Conjugation - Glutathione Conjugation	Tacrine hydrochloride	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Tacrine hydrochloride		DR1523	Approved		Alzheimer disease

References
1	Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity. Clin Pharmacol Ther. 2000 Apr;67(4):432-7.

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