Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000801)
DM Name	11-dehydrodexamethasone

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)	DME0419	Dexamethasone sodium phosphate	Reduction - Reduction	Dexamethasone sodium phosphate	[1] , [2]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)	DME0419	NOVA-63035	Reduction - Reduction	NOVA-63035	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DME0199	Dexamethasone	Unclear - Unclear	Dexamethasone sodium phosphate	[1] , [2]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)	DME0419	Dexamethasone	Reduction - Reduction	NOVA-63035	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Dexamethasone sodium phosphate		DR0461	Approved		Ataxia-telangiectasia

NOVA-63035		DR0457	Phase 1/2		Choroidal neovascularization

References
1	Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction J Clin Endocrinol Metab. 1997 May;82(5):1598-602. doi: 10.1210/jcem.82.5.3936.
2	Metabolism of synthetic corticosteroids by 11 beta-hydroxysteroid-dehydrogenases in man Steroids. 1998 May-Jun;63(5-6):271-7. doi: 10.1016/s0039-128x(98)00039-7.

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