| General Information of Drug Metabolite (DM) (ID: DM001311) |
| DM Name |
Sibutramine metabolite M1
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Demethylation |
Sibutramine
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Sibutramine |
DR1479
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Approved |
Obesity |
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| References |
| 1 |
Sibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity. Ann Pharmacother. 1999 Sep;33(9):968-78.
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| 2 |
Metabolic analysis of the illegal analogues of anti-obesity drugs using LC-Q-TOF-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jan 15;1163:122502. doi: 10.1016/j.jchromb.2020.122502.
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