Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM001328)
DM Name	Amlodipine besylate metabolite M9

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Amlodipine besylate	Oxidation - Dehydrogenation	Amlodipine besylate	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Amlodipine besylate	Oxidation - Dehydrogenation	Amlodipine maleate	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Amlodipine besylate		DR0098	Approved		Essential hypertension

Amlodipine maleate		DR0099	Approved		Essential hypertension

References
1	Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation. Drug Metab Dispos. 2014 Feb;42(2):245-9.

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