General Information of Drug Metabolite (DM) (ID: DM001987)
DM Name
Erdafitinib metabolite M5
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Oxidation - O-Demethylation Erdafitinib [1]
Full List of Drug(s) That Produce This DM By Metabolism
Erdafitinib DR0595 Approved Renal cell carcinoma
References
1 Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor Xenobiotica. 2021 Feb;51(2):177-193. doi: 10.1080/00498254.2020.1821123.

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