| General Information of Drug Metabolite (DM) (ID: DM002724) |
| DM Name |
Cytochrome P-450-metabolite complexes
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 (CYP)
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DMEN060
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| Unclear - Unclear |
Oleandomycin
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Oleandomycin |
DR1189
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Phase 4 |
Acute upper respiratory infection |
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| References |
| 1 |
Formation of inactive cytochrome P-450 Fe(II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in rats Biochem Pharmacol. 1983 May 1;32(9):1487-93. doi: 10.1016/0006-2952(83)90470-7.
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| 2 |
Self-induction by oleandomycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450. Comparison with troleandomycin J Pharmacol Exp Ther. 1982 Apr;221(1):215-21.
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