| General Information of Drug Metabolite (DM) (ID: DM002850) |
| DM Name |
M-2
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - N-Oxidation |
Pinacidil
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Pinacidil |
DR1292
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Approved |
Essential hypertension |
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| References |
| 1 |
Cytochrome P450 3A4-mediated oxidative conversion of a cyano to an amide group in the metabolism of pinacidil. Biochemistry. 2002 Feb 26;41(8):2712-8.
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