General Information of Drug Metabolite (DM) (ID: DM003465)
DM Name
H3B-6527 Metabolite M807
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Gamma-glutamyltranspeptidase 5 (GGT5) DME0432 Hydrolysis - Hydrolysis H3B-6527 [1]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
amino dipeptidases (AMD) DMEN123 Unclear - Unclear H3B-6527 [1]
Full List of Drug(s) That Produce This DM By Metabolism
H3B-6527 DR1800 Phase 1 Hepatocellular carcinoma
References
1 Correlation of the in vitro biotransformation of H3B-6527 in dog and human hepatocytes with the in vivo metabolic profile of 14C-H3B-6527 in a dog mass balance study. Xenobiotica. 2020 Apr;50(4):458-467.

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