| General Information of Drug Metabolite (DM) (ID: DM003515) |
| DM Name |
MK-7246 Metabolite M3
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 2B17 (UGT2B17)
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DME0066
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| Conjugation - Glucuronidation |
MK-7246
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| MK-7246 |
DR1806
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Phase 1 |
Asthma |
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| References |
| 1 |
UGT2B17 genetic polymorphisms dramatically affect the pharmacokinetics of MK-7246 in healthy subjects in a first-in-human study. Clin Pharmacol Ther. 2012 Jul;92(1):96-102.
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