| General Information of Drug Metabolite (DM) (ID: DM004237) |
| DM Name |
PCI-48303 (M26)
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Glutathione S-transferase pi (GSTP1)
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DME0088
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| Conjugation - Glutathione conjugation |
Ibrutinib
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[1] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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Gamma-glutamyltranspeptidase 5 (GGT5)
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DME0432
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| Unclear - Unclear |
Ibrutinib
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[2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Ibrutinib |
DR0843
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Approved |
Mantle cell lymphoma |
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| References |
| 1 |
Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.
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| 2 |
Extrahepatic metabolism of ibrutinib
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