| General Information of Drug Metabolite (DM) (ID: DM005118) |
| DM Name |
Nifurtimox M17
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Oxygen-insensitive NADPH nitroreductase B (nfsB)
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DME1048
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| Reduction - Reduction |
Nifurtimox
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Nifurtimox |
DR5350
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Approved |
Chagas disease |
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| References |
| 1 |
Structural and Mechanistic Investigation of the Unusual Metabolism of Nifurtimox
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| 2 |
Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites
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