Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM005180)
DM Name
Phenylbutenoyl-CoA
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Enoyl-CoA hydratase (ECHS1) DMEN259
Beta-Hydroxyphenylbutyryl-CoA
Unclear - Unclear Sodium phenylbutyrate [1]
Enoyl-CoA hydratase (ECHS1) DMEN259
Beta-Hydroxyphenylbutyryl-CoA
Unclear - Unclear Phenylbutyrate [2]
Full List of Drug(s) That Produce This DM By Metabolism
Sodium phenylbutyrate DR5509 Approved Muscular atrophy
Phenylbutyrate DR3191 Phase 2 Phenylketonuria
References
1 Evidence for involvement of medium chain acyl-CoA dehydrogenase in the metabolism of phenylbutyrate
2 Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control

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