| General Information of Drug Metabolite (DM) (ID: DM005650) |
| DM Name |
Bedaquiline fumarate Metabolite M2
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - N-demethylation |
Bedaquiline fumarate
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Bedaquiline fumarate |
DR0182
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Approved |
Pulmonary tuberculosis |
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| References |
| 1 |
Bedaquiline metabolism: enzymes and novel metabolites. Drug Metab Dispos. 2014 May;42(5):863-6.
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| 2 |
Effects of Rifamycin Coadministration on Bedaquiline Desmethylation in Healthy Adult Volunteers
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