| General Information of Drug Metabolite (DM) (ID: DM006345) |
| DM Name |
12-OH-sirolimus
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Aliphatic hydroxylation |
Sirolimus
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Sirolimus |
DR1489
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Approved |
Lymphangioleiomyomatosis |
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| References |
| 1 |
Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
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