| General Information of Drug Metabolite (DM) (ID: DM006680) |
| DM Name |
7-amino-unitrazepam
|
|
|
|
|
|
|
|
| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Oxygen-insensitive NADPH nitroreductase B (nfsB)
|
DME1048
|
| Reduction - Reduction |
Flunitrazepam
|
[1] , [2] , [3] |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Full List of Drug(s) That Produce This DM By Metabolism |
| Flunitrazepam |
DR0712
|
Phase 4 |
Insomnia |
|
|
| References |
| 1 |
Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis. Biochem Pharmacol. 2012 Jun 15;83(12):1690-9.
|
| 2 |
NADPH-cytochrome P-450 reductase is involved in flunitrazepam reductive metabolism in Hep G2 and Hep 3B cells
|
| 3 |
Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4. Xenobiotica. 1999 Oct;29(10):973-86.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
