Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM006704)
DM Name	Nitrite
Synonyms	nitrite\|Nitrite Ion\|14797-65-0\|Nitrite anion\|Nitrous acid, ion(1-)\|Nitrites\|Nitrite(1-)\|Nitrite (NO2-)\|Nitrite ion (NO2-)\|Nitrogen dioxide ion(1-)\|Nitrogen peroxide ion(1-)\|NO2-\|UNII-J39976L608\|Nitrite as N @ 1000 microg/mL in H2O\|J39976L608\|NO2?\|Nitrite Standard: NO2- @ 1000 microg/mL in H2O\|Nitrite Standard: NO2- @ 10000 microg/mL in H2O\|Nitrit\|Nitrite Standard\|dioxonitrate(1-)\|dioxonitrate(III)\|dioxidonitrate(1-)\|ONO-\|CHEMBL1361\|N-O2\|DTXSID5024219\|BDBM26989\|CHEBI:16301\|IOVCWXUNBOPUCH-UHFFFAOYSA-M\|MFCD00144923\|NA2627\|NO2(-)\|UN2627\|DB12529\|Water Supply QC Check Sample: Nitrite\|NCGC00090737-03\|NCGC00090737-04\|[NO2](-)\|LS-193697\|Nitrite as N @ 10000 microg/mL in H2O\|AB01566909_01\|Q213788
Structure
Structure	3D MOL			2D MOL
Pharmaceutical Properties	Molecular Weight		46.006	Topological Polar Surface Area		52.5
	Heavy Atom Count		3	Rotatable Bond Count		0
	Hydrogen Bond Donor Count		0	Hydrogen Bond Acceptor Count		3
PubChem CID	946
Complexity	7.5
Formula	NO2-
Canonical SMILES	N(=O)[O-]
InChI	InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1
InChIKey	IOVCWXUNBOPUCH-UHFFFAOYSA-M
IUPAC name	nitrite

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytosolic 5'-nucleotidase 1A (NT5C1A)	DMEN710	Nitric Oxide	Oxidation - Oxidation	Nitric Oxide	[1]
Glutathione S-transferase (GST)	DMEN072	Glyceryl trinitrate	Unclear - Unclear	Glyceryl trinitrate	[2]
NADPH-cytochrome P450 reductase (CPR)	DME0076	Nifurtimox	Unclear - Unclear	Nifurtimox	[3]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytosolic 5'-nucleotidase 1A (NT5C1A)	DMEN710	NO3C	Oxidation - Oxidation	Nitric Oxide	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Nifurtimox		DR5350	Approved		Chagas disease

Nitric Oxide		DR5929	Approved		Respiratory failure

Glyceryl trinitrate		DR2513	Phase 4		Acute coronary syndrome

References
1	Pathways Linking Oral Bacteria, Nitric Oxide Metabolism, and Health
2	Nitroglycerin metabolism in vascular tissue: role of glutathione S-transferases and relationship between NO. and NO2- formation
3	Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator

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