General Information of Drug Metabolite (DM) (ID: DM018023)
DM Name
Alpelisib Metabolite M3
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Oxidation Alpelisib [1]
Full List of Drug(s) That Produce This DM By Metabolism
Alpelisib DR0074 Approved Breast cancer
References
1 Absorption, distribution, metabolism, and excretion of [(14)C]BYL719 (alpelisib) in healthy male volunteers. Cancer Chemother Pharmacol. 2015 Oct;76(4):751-60.

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