| General Information of Drug Metabolite (DM) (ID: DM018375) |
| DM Name |
Sulfoxide
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Oxidation |
OSI-930
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| OSI-930 |
DR3091
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Phase 1 |
Solid tumour/cancer |
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| References |
| 1 |
Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug
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