| General Information of Drug Metabolite (DM) (ID: DM018479) |
| DM Name |
ACU-5145
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Cytochrome P450 2D6 (CYP2D6)
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DME0009
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| Oxidation - Hydroxylation |
Emixustat
|
[1] , [2] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Hydroxylation |
Emixustat
|
[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Emixustat |
DR3375
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Phase 2/3 |
Age-related macular degeneration |
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| References |
| 1 |
Oxidative Deamination of Emixustat by Human Vascular Adhesion Protein-1/Semicarbazide-Sensitive Amine Oxidase
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| 2 |
Disposition, profiling and identification of emixustat and its metabolites in humans
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