| General Information of Drug Metabolite (DM) (ID: DM019443) |
| DM Name |
M409-2
|
| Structure |
|
|
3D MOL is unavailable
|
2D MOL is unavailable
|
|
|
|
|
|
|
|
| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Cytochrome P450 2D6 (CYP2D6)
|
DME0009
|
| Oxidation - Mono-oxidation |
Fruquintinib
|
[1] , [2] |
|
Cytochrome P450 3A4 (CYP3A4)
|
DME0001
|
| Oxidation - Mono-oxidation |
Fruquintinib
|
[1] , [2] |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Full List of Drug(s) That Produce This DM By Metabolism |
| Fruquintinib |
DR3419
|
Phase 3 |
Solid tumour/cancer |
|
|
| References |
| 1 |
A simple and rapid infrared-assisted self enzymolysis extraction method for total flavonoid aglycones extraction from Scutellariae Radix and mechanism exploration
|
| 2 |
Preclinical pharmacokinetics and disposition of a novel selective VEGFR inhibitor fruquintinib (HMPL-013) and the prediction of its human pharmacokinetics
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
