| General Information of Drug Metabolite (DM) (ID: DM019453) |
| DM Name |
M409-4
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2D6 (CYP2D6)
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DME0009
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| Oxidation - Mono-oxidation |
Fruquintinib
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[1] , [2] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Mono-oxidation |
Fruquintinib
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Fruquintinib |
DR3419
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Phase 3 |
Solid tumour/cancer |
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| References |
| 1 |
Management of postoperative junctional ectopic tachycardia in pediatric patients: a survey of 30 centers in Germany, Austria, and Switzerland
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| 2 |
Preclinical pharmacokinetics and disposition of a novel selective VEGFR inhibitor fruquintinib (HMPL-013) and the prediction of its human pharmacokinetics
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