General Information of Drug Metabolite (DM) (ID: DM019894)
DM Name
LY-2603618 Metabolite H2
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Oxidation - Hydroxylation LY-2603618 [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Hydroxylation LY-2603618 [1]
Full List of Drug(s) That Produce This DM By Metabolism
LY-2603618 DR1846 Phase 2 Pancreatic cancer
References
1 Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors. Xenobiotica. 2014 Sep;44(9):827-41.

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