| General Information of Drug Metabolite (DM) (ID: DM019894) |
| DM Name |
LY-2603618 Metabolite H2
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2D6 (CYP2D6)
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DME0009
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| Oxidation - Hydroxylation |
LY-2603618
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[1] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Hydroxylation |
LY-2603618
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| LY-2603618 |
DR1846
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Phase 2 |
Pancreatic cancer |
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| References |
| 1 |
Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors. Xenobiotica. 2014 Sep;44(9):827-41.
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