General Information of Drug Metabolite (DM) (ID: DM001150)
DM Name
Palbociclib metabolite M2
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Hydroxylation Palbociclib [1]
Full List of Drug(s) That Produce This DM By Metabolism
Palbociclib DR1229 Approved Breast cancer
References
1 In vitro and in vivo metabolic investigation of the Palbociclib by UHPLC-Q-TOF/MS/MS and in silico toxicity studies of its metabolites J Pharm Biomed Anal. 2018 Aug 5;157:59-74. doi: 10.1016/j.jpba.2018.05.008.

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