| General Information of Drug Metabolite (DM) (ID: DM001150) |
| DM Name |
Palbociclib metabolite M2
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Hydroxylation |
Palbociclib
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Palbociclib |
DR1229
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Approved |
Breast cancer |
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| References |
| 1 |
In vitro and in vivo metabolic investigation of the Palbociclib by UHPLC-Q-TOF/MS/MS and in silico toxicity studies of its metabolites J Pharm Biomed Anal. 2018 Aug 5;157:59-74. doi: 10.1016/j.jpba.2018.05.008.
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