| General Information of Drug Metabolite (DM) (ID: DM002540) |
| DM Name |
Cyclic prodrug of Adefovir 3
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Unclear - Unclear |
Adefovir
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[1] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Unclear - Unclear |
ICN-2001-3
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Adefovir |
DR5457
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Approved |
Hepatitis B virus infection |
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| ICN-2001-3 |
DR1827
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Phase 2 |
Viral hepatitis |
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| References |
| 1 |
Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B J Med Chem. 2008 Feb 14;51(3):666-76. doi: 10.1021/jm7012216.
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