| General Information of Drug Metabolite (DM) (ID: DM002572) |
| DM Name |
10-O-demethylemetine
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2D6 (CYP2D6)
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DME0009
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| Oxidation - Demethylation |
Q-100155
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[1] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Demethylation |
Q-100155
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[1] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Demethylation |
Ipecac
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[2] , [3] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Ipecac |
DR0877
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Phase 4 |
Pulmonary tuberculosis |
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| Q-100155 |
DR0571
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Preclinical |
Rheumatoid arthritis |
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| References |
| 1 |
Poncirin and its metabolite ponciretin attenuate colitis in mice by inhibiting LPS binding on TLR4 of macrophages and correcting Th17/Treg imbalance
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| 2 |
Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biol Pharm Bull. 2001 Jun;24(6):678-82.
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| 3 |
Biotransformation of the ipecac alkaloids cephaeline and emetine from ipecac syrup in rats Eur J Drug Metab Pharmacokinet. 2002 Jan-Mar;27(1):29-35. doi: 10.1007/BF03190402.
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