| General Information of Drug Metabolite (DM) (ID: DM005437) |
| DM Name |
HO-PEG4-Naloxol
|
|
|
|
|
|
|
|
| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Cytochrome P450 3A4 (CYP3A4)
|
DME0001
|
| Oxidation - Hydrolyzationn |
Naloxegol oxalate
|
[1] , [2] |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Full List of Drug(s) That Produce This DM By Metabolism |
| Naloxegol oxalate |
DR1126
|
Approved |
Opioid-induced constipation |
|
|
| References |
| 1 |
Absorption, distribution, metabolism, and excretion of [14C]-labeled naloxegol in healthy subjects
|
| 2 |
Naloxegol: treatment for opioid-induced constipation in chronic non-cancer pain. Ann Pharmacother. 2015 Mar;49(3):360-5.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
