| General Information of Drug Metabolite (DM) (ID: DM006390) |
| DM Name |
Enalapril demethylation
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - N-Demethylation |
Enalapril
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Enalapril |
DR0573
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Approved |
Essential hypertension |
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| References |
| 1 |
Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models. Biopharm Drug Dispos. 2015 Sep;36(6):385-397.
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