| General Information of Drug Metabolite (DM) (ID: DM017903) |
| DM Name |
Regorafenib M3
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2J2 (CYP2J2)
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DME0031
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| Oxidation - Hydroxylation |
Regorafenib
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[1] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Hydroxylation |
Regorafenib
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[1] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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Alcohol dehydrogenase (ADH)
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DME1317
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| Oxidation - N-demethylation |
Regorafenib
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Regorafenib |
DR1401
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Approved |
Colon cancer |
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| References |
| 1 |
Mass balance, metabolic disposition, and pharmacokinetics of a single oral dose of regorafenib in healthy human subjects
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