Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0085)
Drug Name
Amifostine
Synonyms
Amifostine (USP); Amifostine 3H2O; Amifostine [USAN:USP:INN:BAN]; Amifostine trihydrate; Anifostine trihydrate; ETHYOL (TN); Ethyol trihydrate; M487QF2F4V; TXQPXJKRNHJWAX-UHFFFAOYSA-N; WR-2721; WR2721; 112901-68-5; 2-(3-aminopropylamino)ethylsulfanylphosphonic acid trihydrate; AC1L3WIM; C5H15N2O3PS.3H2O; DTXSID40150210; Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester), trihydrate; KS-00000U5L; NSC 296961; S-(2-((3-Aminopropyl)amino)ethyl) dihydrogen phosphorothioate, trihydrate; UNII-M487QF2F4V; s4298
Indication Neutropenia [ICD11: 4B00] Approved [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 268.27 Topological Polar Surface Area 124
Heavy Atom Count 15 Rotatable Bond Count 7
Hydrogen Bond Donor Count 7 Hydrogen Bond Acceptor Count 9
Cross-matching ID
PubChem CID
148139
CAS Number
20537-88-6
TTD Drug ID
D06CIE
Formula
C5H21N2O6PS
Canonical SMILES
P(=O)(SCCNCCCN)(O)O
InChI
1S/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2
InChIKey
TXQPXJKRNHJWAX-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
WR-1065 DM018031 N. A. Unclear - Unclear 1 [2]
WR-33278 DM018032 N. A. Oxidation - Oxidation 2 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR009852 Amifostine WR-1065 Unclear - Unclear ALPG [2]
MR009853 WR-1065 WR-33278 Oxidation - Oxidation Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Alkaline phosphatase (ALPL) DME0079 Homo sapiens
PPBT_HUMAN
3.1.3.1
[2]
References
1 Amifostine was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Pharmacokinetic profile of amifostine. Semin Oncol. 1996 Aug;23(4 Suppl 8):18-22.
3 Amifostine (Ethyol): pharmacokinetic and pharmacodynamic effects in vivo

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